Härtel, C; Bialek, R; Enders, M; Gille, C; Handrick, W Syphilis Buchkapitel mit eigenem Titel Bialek, Ralf; Berner, Reinhard; Forster, Johannes; Härtel, Christoph; Heininger, Ulrich; Huppertz, Hans-Iko; Liese, Johannes G; Nadal, David; Simon, Arne (Hrsg.): DGPI-Handbuch, S. 764–769, Thieme, Stuttgart, 2018, ISBN: 978-3-13-240790-9. @incollection{Hartel.2018,
title = {Syphilis},
author = {C H\"{a}rtel and R Bialek and M Enders and C Gille and W Handrick},
editor = {Ralf Bialek and Reinhard Berner and Johannes Forster and Christoph H\"{a}rtel and Ulrich Heininger and Hans-Iko Huppertz and Johannes G Liese and David Nadal and Arne Simon},
isbn = {978-3-13-240790-9},
year = {2018},
date = {2018-01-01},
booktitle = {DGPI-Handbuch},
pages = {764--769},
publisher = {Thieme},
address = {Stuttgart},
keywords = {},
pubstate = {published},
tppubtype = {incollection}
}
|
Enders, M; Gleich, M; Mühlbacher, A; Sakuldamrongpanich, T; Turhan, A; Sertöz, R; Semprini, S; Sambri, V Reply to "Better method for evaluating a new laboratory test for syphilis" Artikel Clinical and vaccine immunology : CVI, 22 (5), S. 607–608, 2015, ISSN: 1556-6811. Links @article{Enders.2015,
title = {Reply to "Better method for evaluating a new laboratory test for syphilis"},
author = {M Enders and M Gleich and A M\"{u}hlbacher and T Sakuldamrongpanich and A Turhan and R Sert\"{o}z and S Semprini and V Sambri},
doi = {10.1128/CVI.00109-15},
issn = {1556-6811},
year = {2015},
date = {2015-01-01},
journal = {Clinical and vaccine immunology : CVI},
volume = {22},
number = {5},
pages = {607--608},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Enders, M; Hunjet, A; Gleich, M; Imdahl, R; Mühlbacher, A; Schennach, H; Chaiwong, K; Sakuldamrongpanich, T; Turhan, A; Sertoz, R; Wolf, E; Mayer, W; Tao, C; Wang, L L; Semprini, S; Sambri, V Performance evaluation of the Elecsys syphilis assay for the detection of total antibodies to Treponema pallidum Artikel Clinical and vaccine immunology : CVI, 22 (1), S. 17–26, 2015, ISSN: 1556-6811. Abstract | Links @article{Enders.2015b,
title = {Performance evaluation of the Elecsys syphilis assay for the detection of total antibodies to Treponema pallidum},
author = {M Enders and A Hunjet and M Gleich and R Imdahl and A M\"{u}hlbacher and H Schennach and K Chaiwong and T Sakuldamrongpanich and A Turhan and R Sertoz and E Wolf and W Mayer and C Tao and L L Wang and S Semprini and V Sambri},
doi = {10.1128/CVI.00505-14.},
issn = {1556-6811},
year = {2015},
date = {2015-01-01},
journal = {Clinical and vaccine immunology : CVI},
volume = {22},
number = {1},
pages = {17--26},
abstract = {Syphilis is a health problem of increasing incidence in recent years that may have severe complications if not diagnosed and treated at an early stage. There are many diagnostic tests available for syphilis, but there is no gold standard, and diagnosis therefore usually relies upon a combination of tests. In this multicenter study, we evaluated the treponemal Elecsys syphilis assay for use in the diagnosis of syphilis in routine samples, i.e., when syphilis is suspected or during antenatal or blood donation screening. The sensitivity and specificity of the Elecsys syphilis assay were compared head to head with those of other treponemal assays used in routine clinical practice and were assessed in potentially cross-reactive samples from patients with Epstein-Barr virus, HIV, and Lyme disease. In a total of 8,063 syphilis-negative samples collected from routine diagnostic requests and blood donations, the Elecsys syphilis assay had a specificity of 99.88%. In 928 samples previously identified as syphilis positive, the sensitivity was 99.57 to 100% (the result is presented as a range depending on whether four initially indeterminate samples are included in the assessment). The specificity of the Elecsys syphilis assay in patients with other infections was 100%; no false-positive samples were identified},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Syphilis is a health problem of increasing incidence in recent years that may have severe complications if not diagnosed and treated at an early stage. There are many diagnostic tests available for syphilis, but there is no gold standard, and diagnosis therefore usually relies upon a combination of tests. In this multicenter study, we evaluated the treponemal Elecsys syphilis assay for use in the diagnosis of syphilis in routine samples, i.e., when syphilis is suspected or during antenatal or blood donation screening. The sensitivity and specificity of the Elecsys syphilis assay were compared head to head with those of other treponemal assays used in routine clinical practice and were assessed in potentially cross-reactive samples from patients with Epstein-Barr virus, HIV, and Lyme disease. In a total of 8,063 syphilis-negative samples collected from routine diagnostic requests and blood donations, the Elecsys syphilis assay had a specificity of 99.88%. In 928 samples previously identified as syphilis positive, the sensitivity was 99.57 to 100% (the result is presented as a range depending on whether four initially indeterminate samples are included in the assessment). The specificity of the Elecsys syphilis assay in patients with other infections was 100%; no false-positive samples were identified |
Schöfer, H; Weberschock, T; Bräuninger, Wolfgang; Bremer, Viviane; Dreher, A; Enders, Martin; Esser, S; Hamouda, O; Hagedorn, H J; Handrick, W; Krause, W; Mayr, C; Münstermann, D; Nast, A; Ochsendorf, F; Petry, U; Potthoff, A; Prange, H; Rieg, S; Schneede, P; Sing, A; Weber, J; Wichelhaus, T A; Brockmeyer, Norbert S2k guideline "Diagnosis and therapy of syphilis"--short version Artikel Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 13 (5), S. 472–480, 2015, ISSN: 1610-0379. Links @article{Schofer.2015,
title = {S2k guideline "Diagnosis and therapy of syphilis"--short version},
author = {H Sch\"{o}fer and T Weberschock and Wolfgang Br\"{a}uninger and Viviane Bremer and A Dreher and Martin Enders and S Esser and O Hamouda and H J Hagedorn and W Handrick and W Krause and C Mayr and D M\"{u}nstermann and A Nast and F Ochsendorf and U Petry and A Potthoff and H Prange and S Rieg and P Schneede and A Sing and J Weber and T A Wichelhaus and Norbert Brockmeyer},
doi = {10.1111/ddg.12574},
issn = {1610-0379},
year = {2015},
date = {2015-01-01},
journal = {Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG},
volume = {13},
number = {5},
pages = {472--480},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Enders, M; Handrick, W Syphilis Buchkapitel mit eigenem Titel Friese, K; Mylonas, Ioannis; Schulze, A (Hrsg.): Infektionserkrankungen der Schwangeren und des Neugeborenen, 3 , S. 371–385, Springer-Verlag, Berlin, Heidelberg, 2013, ISBN: 13 978-3-540-78324-4. @incollection{Enders.2013,
title = {Syphilis},
author = {M Enders and W Handrick},
editor = {K Friese and Ioannis Mylonas and A Schulze},
isbn = {13 978-3-540-78324-4},
year = {2013},
date = {2013-01-01},
booktitle = {Infektionserkrankungen der Schwangeren und des Neugeborenen},
volume = {3},
pages = {371--385},
publisher = {Springer-Verlag},
address = {Berlin, Heidelberg},
keywords = {},
pubstate = {published},
tppubtype = {incollection}
}
|
Enders, M; Handrick, W; Schroten, H Syphilis Buchkapitel mit eigenem Titel Berner, R; Bialek, R; Borte, M; Forster, J; Heininger, U; Liese, J G; Nadal, D; Roos, R; Scholz, H (Hrsg.): DGPI Handbuch, 6 , S. 521–526, Georg Thieme Verlag, Stuttgart, New York, 2013, ISBN: 978-3-13-144716-6. @incollection{Enders.2013c,
title = {Syphilis},
author = {M Enders and W Handrick and H Schroten},
editor = {R Berner and R Bialek and M Borte and J Forster and U Heininger and J G Liese and D Nadal and R Roos and H Scholz},
isbn = {978-3-13-144716-6},
year = {2013},
date = {2013-01-01},
booktitle = {DGPI Handbuch},
volume = {6},
pages = {521--526},
publisher = {Georg Thieme Verlag},
address = {Stuttgart, New York},
keywords = {},
pubstate = {published},
tppubtype = {incollection}
}
|
Handrick, W; Enders, Martin; Borte, M Konnatale Syphilis - es gibt sie noch! Artikel pädiatrische praxis, 76 (3), S. 445–450, 2011. @article{Handrick.2011,
title = {Konnatale Syphilis - es gibt sie noch!},
author = {W Handrick and Martin Enders and M Borte},
year = {2011},
date = {2011-01-01},
journal = {p\"{a}diatrische praxis},
volume = {76},
number = {3},
pages = {445--450},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Enders, Martin; Regnath, T; Tewald, Friedemann; Hassler, D [Syphilis] Artikel Deutsche Medizinische Wochenschrift, 132 (3), S. 77–78, 2007, ISSN: 0012-0472. @article{Enders.2007b,
title = {[Syphilis]},
author = {Martin Enders and T Regnath and Friedemann Tewald and D Hassler},
issn = {0012-0472},
year = {2007},
date = {2007-01-01},
journal = {Deutsche Medizinische Wochenschrift},
volume = {132},
number = {3},
pages = {77--78},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
|
Enders, Martin; Knaub, I; Gohl, M; Pieper, I; Bialek, C; Hagedorn, H J [Congenital syphilis despite prenatal screening? An evaluation of 14 cases] Artikel Zeitschrift fur Geburtshilfe und Neonatologie, 210 (4), S. 141–146, 2006, ISSN: 0948-2393. Abstract @article{Enders.2006b,
title = {[Congenital syphilis despite prenatal screening? An evaluation of 14 cases]},
author = {Martin Enders and I Knaub and M Gohl and I Pieper and C Bialek and H J Hagedorn},
issn = {0948-2393},
year = {2006},
date = {2006-01-01},
journal = {Zeitschrift fur Geburtshilfe und Neonatologie},
volume = {210},
number = {4},
pages = {141--146},
abstract = {BACKGROUND: Congenital syphilis (CS) can be effectively avoided by adequate treatment of the mother during pregnancy. Nevertheless, in recent years, the Robert Koch Institute has reported 6-8 of CS cases per year. The aim of this study was to investigate cases of CS with regard to obstetrical history and results of maternal syphilis serology during pregnancy and postpartum. PATIENTS AND METHODS: Between 1997 and 2001, a total of 14 cases of CS were diagnosed after birth in the Stuttgart laboratory. Information on clinical and serological data obtained during prenatal care and at birth had been provided by the treating gynaecologists and paediatricians. Furthermore, serum samples from 11 of the 14 mothers were investigated at the Stuttgart laboratory after birth and also retrospectively at the Herford laboratory. RESULTS: All mothers presented without clinical signs of syphilis. Delayed prenatal care was observed in 6 out of 14 cases. Eleven of the 14 mothers had a positive treponemal screening test. Treatment was initiated only in two of them. During pregnancy treponemal IgM and cardiolipin antibodies were detected in none of 9 and in 5 of 8 sera of untreated mothers, respectively. In contrast, maternal serum samples investigated after birth were all positive for cardiolipin antibodies and 7 of 10 serum samples were positive for TP IgM antibodies. CONCLUSIONS: Delayed or absent prenatal care and misinterpretation of syphilis serology (or laboratory failures) in the presence of latent syphilis are mostly responsible for the inadequate management of syphilis during pregnancy and thus the occurrence of CS},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND: Congenital syphilis (CS) can be effectively avoided by adequate treatment of the mother during pregnancy. Nevertheless, in recent years, the Robert Koch Institute has reported 6-8 of CS cases per year. The aim of this study was to investigate cases of CS with regard to obstetrical history and results of maternal syphilis serology during pregnancy and postpartum. PATIENTS AND METHODS: Between 1997 and 2001, a total of 14 cases of CS were diagnosed after birth in the Stuttgart laboratory. Information on clinical and serological data obtained during prenatal care and at birth had been provided by the treating gynaecologists and paediatricians. Furthermore, serum samples from 11 of the 14 mothers were investigated at the Stuttgart laboratory after birth and also retrospectively at the Herford laboratory. RESULTS: All mothers presented without clinical signs of syphilis. Delayed prenatal care was observed in 6 out of 14 cases. Eleven of the 14 mothers had a positive treponemal screening test. Treatment was initiated only in two of them. During pregnancy treponemal IgM and cardiolipin antibodies were detected in none of 9 and in 5 of 8 sera of untreated mothers, respectively. In contrast, maternal serum samples investigated after birth were all positive for cardiolipin antibodies and 7 of 10 serum samples were positive for TP IgM antibodies. CONCLUSIONS: Delayed or absent prenatal care and misinterpretation of syphilis serology (or laboratory failures) in the presence of latent syphilis are mostly responsible for the inadequate management of syphilis during pregnancy and thus the occurrence of CS |
Enders, Martin; Hagedorn, H J [Syphilis in pregnancy] Artikel Zeitschrift fur Geburtshilfe und Neonatologie, 206 (4), S. 131–137, 2002, ISSN: 0948-2393. Abstract @article{Enders.2002,
title = {[Syphilis in pregnancy]},
author = {Martin Enders and H J Hagedorn},
issn = {0948-2393},
year = {2002},
date = {2002-01-01},
journal = {Zeitschrift fur Geburtshilfe und Neonatologie},
volume = {206},
number = {4},
pages = {131--137},
abstract = {Syphilis, a sexually transmitted infection, has a major impact on the disease burden worldwide. Globally, an estimated 12 million new cases of sexually acquired syphilis occurred in 1997. Developing countries in Africa, Southeast Asia and regions of the former Soviet Union are mainly affected. With rising numbers of human immunodeficiency virus-infected pregnant women and an increase in gonorrhoea in some areas, the incidence of syphilis is expected to increase again. As a consequence of migration from Eastern bloc countries to Europe after the breakdown of the former Soviet Union, the resurgence of syphilis will also affect Germany. Therefore, we present the clinical picture of syphilis as well as review the current recommendations of the German STD Society, the Centers of Disease Control (CDC), USA, and the Clinical Effectiveness Group (CEG), England, for diagnosis and treatment of syphilis with special emphasis on pregnancy. Considering the current epidemiological situation, physicians should include syphilis in their differential diagnosis. Although recommended therapy regimens differ, penicillin is the treatment of choice. Pregnant patients who are allergic to penicillin should be desensitized and treated with penicillin. Early recognition and timely treatment of syphilis are essential to prevent or treat potentially fatal fetal infection},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Syphilis, a sexually transmitted infection, has a major impact on the disease burden worldwide. Globally, an estimated 12 million new cases of sexually acquired syphilis occurred in 1997. Developing countries in Africa, Southeast Asia and regions of the former Soviet Union are mainly affected. With rising numbers of human immunodeficiency virus-infected pregnant women and an increase in gonorrhoea in some areas, the incidence of syphilis is expected to increase again. As a consequence of migration from Eastern bloc countries to Europe after the breakdown of the former Soviet Union, the resurgence of syphilis will also affect Germany. Therefore, we present the clinical picture of syphilis as well as review the current recommendations of the German STD Society, the Centers of Disease Control (CDC), USA, and the Clinical Effectiveness Group (CEG), England, for diagnosis and treatment of syphilis with special emphasis on pregnancy. Considering the current epidemiological situation, physicians should include syphilis in their differential diagnosis. Although recommended therapy regimens differ, penicillin is the treatment of choice. Pregnant patients who are allergic to penicillin should be desensitized and treated with penicillin. Early recognition and timely treatment of syphilis are essential to prevent or treat potentially fatal fetal infection |
